Answer:

1 O
2 P
3 E
4 R
5 A

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Definition
n. A drama, either tragic or comic, of which music forms an essential part; a drama wholly or mostly sung, consisting of recitative, arials, choruses, duets, trios, etc., with orchestral accompaniment, preludes, and interludes, together with appropriate costumes, scenery, and action; a lyric drama.
n. The score of a musical drama, either written or in print; a play set to music.
n. The house where operas are exhibited.
pl. of Opus

Answers Like OPERA
OPRY OVER OPER OVARY OVERHEAR OPRAH